MECHANISMS OF ACTION OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
Keywords:
heart failure, cardiac suction, myocardium, protodiastolic phaseAbstract
Identify the relationship between the parameters that determine the deterioration of the protodiastolic phase of left ventricular suction with heart failure with preserved ejection fraction. Two groups were formed: (1) Group I: Ten patients without heart disease; and (2) Group II: Ten patients with heart failure and preserved ejection fraction. All patients were in Sinus rhythm. Studies were performed: Doppler echocardiography, Cardiac cycle (ms); Left ventricular systole (ms); Protodiastolic phase of left ventricular myocardial contraction (ms); Left ventricular diastole (ms); Right ventricular systole (ms); Protodiastolic phase of right ventricular myocardial contraction (ms); Right ventricular diastole (ms); Relative wall thickness (%); Left ventricular mass (g/m2); E/E´ ratio; Left ventricular ejection fraction (%); Volume left atrium (ml/m2); Pulmonary arterial pressure (mmHG) and Left ventricular end-systolic volume (ml). In all patients in the Group II there is a longer time of the protodiastolic phase of myocardial contraction of the left ventricle: 134 ms, compared to the group without heart disease (Group I): 83ms (p<0.01). An increase in left ventricular mass was found in Group II with an average of 106 gr/m2 in relation to the normal group (67 gr/m2) (<0.01); Relative wall thickness, which went from 0.33% to 0.49% (<0.01) and left atrial volume, which reached 43 ml/m2 for a control group value of 19 ml/m2 (<0.01). The mechanism of heart failure with preserved ejection fraction is mainly due to left ventricular suction dysfunction, excessively prolonged during the protodiastolic phase, compared to the control group, which would lead to increased pressures filling of the cardiac chambers.
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Copyright (c) 2024 JORGE TRAININI, MAYRA PATRICIA HERNANDEZ LOPEZ, MARIA ELENA BASTARRICA, ALEJANDRO TRAININI, JESUS VALLE CABEZAS, FRANCESC CARRERAS COSTA, JORGE LOWENSTEIN, VICENTE MORA LIABATA
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