IN-VITRO COMPARATIVE QUALITY EVALUATION OF DIFFERENT BRANDS OF RANOLAZINE TABLETS MARKETED IN ANDHRA PRADESH, INDIA
Keywords:
Ranolazine hydrochloride, drug quality, hardness, friability, disintegration, drug releaseAbstract
An extended-release tablet provides prolonged periods of drug in plasma levels thereby reduce dosing frequency, improve patient compliance and reduce the dose-related side effects. Ranolazine is indicated for the chronic treatment of angina in patients who have not achieved an adequate response with other anti-anginal agents. In this study, an attempt was made to investigate the in-vitro quality control testing of five different prominent pharmaceutical brands of Ranolazine hydrochloride tablets marketed in Andhra Pradesh, India. Five different brands of tablets used in the study, named brand A, brand B, brand C, brand D, and brand E were evaluated for weight variation, content uniformity, thickness, hardness, disintegration, dissolution, and assay. The study utilized standardized testing methods to ensure consistency and reliability across all assessments. Results revealed that all the brands of Ranolazine tablets complied with the official specification for hardness, friability, disintegration and assay. All the selected brands of Ranolazine tablets complied with the USP dissolution tolerance limits, the tablets demonstrated robust mechanical strength, minimal friability, and prompt disintegration of active pharmaceutical ingredients.
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Copyright (c) 2024 SHANNU SHAIK, BUTHUKURI LAKSHMI PRASANNA, PRATHIKANTAM THARUN KUMAR, SHAIK AFRIN, SIVA KRISHNA PUSULURI, SRINIVASA BABU PUTTAGUNTA, MUNNANGI MUKKANTI ESWARUDU
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