ADAPTIVE IMMUNE SYSTEM OF MALNUTRITION CHILDREN IN TEGALWANGI VILLAGE, CIREBON REGENCY

Authors

  • SITI PANDANWANGI Faculty of Pharmacy, YPIB Majalengka University, West Java, Indonesia.
  • AHMAD AZRUL ZUNIARTO Faculty of Pharmacy, YPIB Majalengka University, West Java, Indonesia.
  • AISYAH Faculty of Pharmacy, YPIB Majalengka University, West Java, Indonesia.
  • HENI Faculty of Health Science, YPIB Majalengka University, West Java, Indonesia.

DOI:

https://doi.org/10.55197/qjmhs.v4i1.107

Keywords:

adaptive immune system, malnutrition, CD4 , IgM

Abstract

Malnutrition consisting of poor nutrition, stunting, and undernutrition is one of the most common health problems in Indonesia. Based on data on the number of malnourished toddlers in Cirebon district, Weru sub-district has a relatively high number, including 208 toddlers with malnutrition, 164 thin toddlers and 281 short toddlers. To determine the adaptive immune system as reviewed from the CD4+ and IgM levels of malnourished children in Tegalwangi Village, Weru District, Cirebon Regency. This type of research is observational research. By using 50 malnourished children as samples in this study. Measurement of CD4+ and IgM levels uses the Elisa (enzyme-linked immunosorbent assay) method. The data analysis technique used is the Chi Square test. From 50 samples of malnourished children in Tegalwangi Village, Weru District, Cirebon Regency, the results obtained were children at risk of low CD4+ levels were boys (OR=0.508, p value>0.05), children aged 42-60 months (OR=1.969, p value>0.05), children with short categories (OR=2.857, p value>0.05) and malnourished children (OR=2.000, p value>0.05). Children at risk of low IgM levels are boys (OR=0.692, p value>0.05), children aged 42-60 months (OR=1.444, p value>0.05), children in the short category (OR=2.550, p value>0.05) and malnourished children (OR=1.385, p value>0.05). It can be concluded that the adaptive immune system of malnourished children in Tegalwangi Village, Weru District, Cirebon Regency is not significant.

References

Aprilia, D. (2022): Perbedaan Risiko Kejadian Stunting Berdasarkan Umur Dan Jenis Kelamin. – Jurnal Kebidanan 11(2): 25-31.

Aulia, A., Rahayu, S.R. (2021): Determinan Perubahan Kadar CD4 pada Orang Dengan HIV/AIDS Koinfeksi TB. – Indonesian Journal of Public Health and Nutrition 1(3): 479-490.

Bayram, R.O., Özdemir, H., Emsen, A., DAĞI, H.T., Artac, H. (2019): Reference ranges for serum immunoglobulin (IgG, IgA, and IgM) and IgG subclass levels in healthy children. – Turkish Journal of Medical Sciences 49(2): 497-505.

Gaayeb, L., Sarr, J.B., Cames, C., Pinçon, C., Hanon, J.B., Ndiath, M.O., Seck, M., Herbert, F., Sagna, A.B., Schacht, A.M., Remoue, F. (2014): Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal. – The American Journal of Tropical Medicine and Hygiene 90(3): 8p.

Ibrahim, M.K., Zambruni, M., Melby, C.L., Melby, P.C. (2017): Impact of childhood malnutrition on host defense and infection. – Clinical Microbiology Reviews 30(4): 919-971.

Indrawanti, R., Arguni, E., Laksanawati, I.S., Puspitasari, D., Husada, D. (2021): Status gizi dan gambaran klinis penyakit pada pasien HIV anak awal terdiagnosis. – Jurnal Gizi Klinik Indonesia 17(3): 125-132.

Kemenkes, R.I. (2004): Decree of the Minister of Health of the Republic of Indonesia Number 1204/Menkes. SK/X/2004 concerning Hospital Environmental Health Requirements (Keputusan Menteri Kesehatan Republik Indonesia Nomor 1204/Menkes/Sk/X/2004 Tentang Persyaratan Kesehatan Lingkungan Rumah Sakit). – Jakarta: Kemenkes RI 64p.

Luckheeram, R.V., Zhou, R., Verma, A.D., Xia, B. (2012): CD4+ T cells: differentiation and functions. – Journal of Immunology Research 12p.

Maragareth, W., Hadisaputro, S., Margawati, A. (2019): The correlation between intake of energy, protein, fat of underweight and CD4+ count for children with HIV. – Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) 6(2): 77-87.

Meinapuri, M., Putri, B.O. (2018): Hubungan kadar imunoglobulin a sekretori air susu ibu dengan berat badan bayi yang mendapat air susu ibu eksklusif. – Majalah Kedokteran Andalas 41(1): 1-9.

Mujahidah, R.I., Faizah, A. (2023): The Relationship Between Nutritional Status and Stunting Toddlers At The Posyandu Pelangi in the Working Area Of The Batu Aji Health Centre in Batam. – Zona Keperawatan: Program Studi Keperawatan Universitas Batam 13(2): 7p.

Mustakim, M.R., Irawan, R., Irmawati, M., Setyoboedi, B. (2022): Impact of Stunting on Development of Children between 1-3 Years of Age. – Ethiopian Journal of Health Sciences 32(3): 569-578.

Nugroho, A.A., Hapsari, M.M., Farida, H. (2014): Faktor Determinan Peningkatan Berat Badan dan Jumlah CD4 Anak HIV/AIDS Setelah Enam Bulan Terapi Antiretroviral Penelitian Cohort retrospective terhadap Usia, Jenis kelamin, Stadium klinis, Lama Terapi Antiretroviral. – Diponegoro University 86p.

Puspito Panggih Rahayu, C. (2020): Perbedaan Risiko Stunting Berdasarkan Jenis Kelamin. – In Prosiding Seminar Nasional Multidisiplin Ilmu 2(1): 135-139.

Sakamoto, S., Putalun, W., Vimolmangkang, S., Phoolcharoen, W., Shoyama, Y., Tanaka, H., Morimoto, S. (2018): Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites. – Journal of Natural Medicines 72: 32-42.

Santosa, B., Iswara, A., Ernanto, A.R. (2019): IR-Bagendit leaves water extract as preventing agent in hematopoiesis, degeneration, and necrosis in kidney tubulus of lead-exposed rats. – Pakistan Journal of Medical and Health Sciences 13(3): 899-904.

Sartika, D., Sanyoto, D.D., Febriana, S.K.T., Adhani, R., Suhartono, E. (2024): Analysis of Factors Associated with the Incidence of Stunting in Toddlers in the Working Area of Ketapang II Health Center, East Kotawaringin Regency. – Journal La Medihealtico 5(2): 346-355.

Thurstans, S., Opondo, C., Seal, A., Wells, J.C., Khara, T., Dolan, C., Briend, A., Myatt, M., Garenne, M., Mertens, A., Sear, R. (2022): Understanding sex differences in childhood undernutrition: a narrative review. – Nutrients 14(5): 15p.

Triawanti, Didik Dwi Sanyoto, Ari Yunanto. (2018): Selected Chapters on Malnutrition. – Sari Mulia 69p.

World Health Organization (WHO) (2021): Malnutrition. – WHO Web Portal 5p.

World Health Organization (WHO), United Nations International Children’s Emergency Fund (UNICEF), World Bank Group (2023): Levels and trends in child malnutrition. – WHO Web Portal 32p.

Widiyanti, M., Sandy, S. (2016): Overview of HIV-1 Subtype with CD4 Levels, Clinical Stage and Opportunistic Infections HIV/AIDS in City and Regency of Jayapura-Papua. – MAJALAH KEDOKTERAN BANDUNG-MKB-BANDUNG MEDICAL JOURNAL 48(1): 1-6.

Winowatan, G., Malonda, N.S., Punuh, M.I. (2017): Hubungan antara berat badan lahir anak dengan kejadian stunting pada anak batita di wilayah kerja puskesmas sonder kabupaten Minahasa. – Kesmas 6(3): 8p.

Yogani, I.T.H.K., Uyainah, A., Koesnoe, S. (2015): Faktor-faktor yang Berhubungan dengan kenaikan CD4 pada pasien HIV yang mendapat highly active antiretroviral therapy dalam 6 bulan pertama. – Jurnal Penyakit dalam Indonesia 2(4): 7p.

Downloads

Published

2025-02-28

Issue

Section

Articles

How to Cite

ADAPTIVE IMMUNE SYSTEM OF MALNUTRITION CHILDREN IN TEGALWANGI VILLAGE, CIREBON REGENCY. (2025). Quantum Journal of Medical and Health Sciences, 4(1), 22-31. https://doi.org/10.55197/qjmhs.v4i1.107