ASSESSMENT OF CARDIOVASCULAR MARKERS AND RISK-FACTORS AMONG NEWLY DIAGNOSED HYPERTENSIVE PATIENTS IN BENIN CITY
DOI:
https://doi.org/10.55197/qjmhs.v4i1.132Keywords:
hypertension, dsylipidemia, atherogenic index, cardiovascular markersAbstract
Hypertension represents a major cardiovascular risk factor and quite often co-exists with dyslipidemia, further increasing the cardiovascular risk. The present study was done with the aim of studying some cardiovascular markers and risk factors in newly diagnosed hypertensive subjects in Benin City. In this present study, a total of 104 participants comprising 52 hypertensive patients and 52 normotensive controls aged between 20 and 80 years were enrolled. Lipid profile, for the following components, namely TC, LDL-C, HDL-C, and TG, was assayed using standard analytic procedures. Demographic data and anthropometric measures were collected. This analysis indicated that most of the parameters of the lipid profile were significantly associated with the risk factors of CVDs. Hypertensive subjects revealed significantly higher mean systolic and diastolic blood pressure values when compared with normotensive subjects (P<0.001). Comparing hypertensive patients with controls revealed a statistically significant increase in the mean±SEM values of TC and LDL-C to 240.35±8.11 and 166.98±7.50, respectively, with P<0.001. Besides, TG was significantly elevated; its value was 112.15±6.96, with P=0.018, while HDL-C failed to show any statistical difference in its values, with 46.38±2.53 in this series, with P=0.365. AIP, CRR, and AC were higher with P<0.001. This study has estimated the prevalence of dyslipidemia and a high atherogenic index among hypertensive patients. Results thus provide support for lipid profile monitoring in hypertensive subjects for reduction in cardiovascular events. Earlier detection and timely treatment of dyslipidemia might definitely render better health to these patients.
References
Alberti, K.G.M., Zimmet, P., Shaw, J. (2005): The metabolic syndrome-a new worldwide definition. – The Lancet 366(9491): 1059-1062.
Allain, C.C., Poon, L.S., Chan, C.S., Richmond, W.F.P.C., Fu, P.C. (1974): Enzymatic determination of total serum cholesterol. – Clinical Chemistry 20(4): 470-475.
Asaolu, M.F., Asaolu, S.S., Fakunle, J.B., Ogunleye, Z.A. (2010): Evaluation of lipid status of hypertensive Nigerians in Ado-Ekiti, western Nigeria. – Der Pharmacia Lettre 2(2): 6-9.
Bonow, R.O., Smaha, L.A., Smith Jr, S.C., Mensah, G.A., Lenfant, C. (2002): World Heart Day 2002: the international burden of cardiovascular disease: responding to the emerging global epidemic. – Circulation 106(13): 1602-1605.
Borghi, C. (2002): Interactions between hypercholesterolemia and hypertension: implications for therapy. – Current Opinion in Nephrology and Hypertension 11(5): 489-496.
Bucolo, G., David, H. (1973): Quantitative determination of serum triglycerides by the use of enzymes. – Clinical Chemistry 19(5): 476-482.
Cannon, C.P., Shah, S., Dansky, H.M., Davidson, M., Brinton, E.A., Gotto Jr, A.M., Stepanavage, M., Liu, S.X., Gibbons, P., Ashraf, T.B., Zafarino, J. (2010): Safety of anacetrapib in patients with or at high risk for coronary heart disease. – New England Journal of Medicine 363(25): 2406-2415.
Castelli, W.P., Anderson, K. (1986): A population at risk: prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. – The American Journal of Medicine 80(2): 23-32.
Chapman, M.J., Ginsberg, H.N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A.L., Descamps, O.S., Fisher, E., Kovanen, P.T., Kuivenhoven, J.A., Lesnik, P. (2011): Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. – European Heart Journal 32(11): 1345-1361.
Cheng, W., Kong, F., Chen, S. (2022): Comparison of the predictive value of four insulin resistance surrogates for the prevalence of hypertension: a population-based study. – Diabetology & Metabolic Syndrome 14(1): 12p.
Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo Jr, J.L., Jones, D.W., Materson, B.J., Oparil, S., Wright Jr, J.T., Roccella, E.J. (2003): The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. – Jama 289(19): 2560-2571.
Correction Naghavi, M., Wang, H., Lozano, R., Davis, A., Liang, X., Zhou, M., Vollset, S.E., Ozgoren, A.A., Abdalla, S., Abd Allah, F., Aziz, M.I.A. (2015): Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. – The Lancet 385(9963): 117-171.
Grundy, S.M., D’Agostino, Sr, R.B., Mosca, L., Burke, G.L., Wilson, P.W., Rader, D.J., Cleeman, J.I., Roccella, E.J., Cutler, J.A., Friedman, L.M. (2001): Cardiovascular risk assessment based on US cohort studies: findings from a National Heart, Lung, and Blood Institute workshop. – Circulation 104(4): 491-496.
Dobiás̆ová, M., Frohlich, J. (2001): The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL). – Clinical Biochemistry 34(7): 583-588.
Dobiášová, M., Frohlich, J., Šedová, M., Cheung, M.C., Brown, B.G. (2011): Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography. – Journal of Lipid Research 52(3): 566-571.
Friedewald, W.T., Levy, R.I., Fredrickson, D.S. (1972): Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. – Clinical Chemistry 18(6): 499-502.
Grundy, S.M. (2006): Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. – Journal of the American College of Cardiology 47(6): 1093-1100.
Guo, F., He, D., Zhang, W., Walton, R.G. (2012): Trends in prevalence, awareness, management, and control of hypertension among United States adults, 1999 to 2010. – Journal of the American College of Cardiology 60(7): 599-606.
Gupta, R. (2004): Trends in hypertension epidemiology in India. – Journal of Human Hypertension 18(2): 73-78.
He, F.J., MacGregor, G.A. (2003): How far should salt intake be reduced? – Hypertension 42(6): 1093-1099.
Idemudia, J.O., Ugwuja, E.I., Idemudia, J. (2009): Plasma lipid profiles in hypertensive Nigerians. – The Internet Journal of Cardiovascular Research 6(2): 6p.
Kannel, W.B., Castelli, W.P., Gordon, T., McNamara, P.M. (1971): Serum cholesterol, lipoproteins, and the risk of coronary heart disease: the Framingham Study. – Annals of Internal Medicine 74(1): 1-12.
Kanthe, P.S., Patil, B.S., Bagali, S., Deshpande, A., Shaikh, G.B., Aithala, M. (2012): Atherogenic index as a predictor of cardiovascular risk among women with different grades of obesity. – International Journal of Collaborative Research on Internal Medicine & Public Health 4(10): 1767-1774.
Kearney, P.M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P.K., He, J. (2005): Global burden of hypertension: analysis of worldwide data. – The Lancet 365(9455): 217-223.
Nauck, M., Warnick, G.R., Rifai, N. (2002): Methods for measurement of LDL-cholesterol: a critical assessment of direct measurement by homogeneous assays versus calculation. – Clinical Chemistry 48(2): 236-254.
Neaton, J.D., Wentworth, D. (1992): Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease overall findings and differences by age for 316099 white men. – Archives of Internal Medicine 152(1): 56-64.
Olafiranye, O., Zizi, F., Brimah, P., Jean-Louis, G., Makaryus, A.N., McFarlane, S., Ogedegbe, G. (2011): Management of hypertension among patients with coronary heart disease. – International Journal of Hypertension 6p.
Osuji, C.U., Omejua, E.G., Onwubuya, E.I., Ahaneku, G.I. (2012): Serum Lipid Profile of Newly Diagnosed Hypertensive Patients in Nnewi, South‐East Nigeria. – International Journal of Hypertension 7p.
Otsuka, H., Tabata, H., Someya, Y., Tamura, Y. (2021): Trends in the prevalence of underweight in women across generations in Japan. – Journal of Bone and Mineral Metabolism 39: 719-720.
Palmieri, V., Bella, J.N., Arnett, D.K., Roman, M.J., Oberman, A., Kitzman, D.W., Hopkins, P.N., Paranicas, M., Rao, D.C., Devereux, R.B. (2001): Aortic root dilatation at sinuses of valsalva and aortic regurgitation in hypertensive and normotensive subjects: The Hypertension Genetic Epidemiology Network Study. – Hypertension 37(5): 1229-1235.
Sami Khaza, M. (2013): Atherogenic index of plasma (AIP) as a parameter in predicting cardiovascular risk in males compared to the conventional dyslipidemic indices (cholesterol ratios). – Kerbala Journal of Medicine 6(1): 1506-1513.
Tan, M.H., Johns, D., Glazer, N.B. (2004): Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes. – Clinical Chemistry 50(7): 1184-1188.
Taylor, G.O., Agbedana, E.O. (1983): A comparative study of plasma high-density lipoprotein cholesterol in two groups of Nigerians of different socio-economic status. – African Journal of Medicine and Medical Sciences 12(1): 23-28.
World Health Organization (WHO) (2013): A Global Brief on Hypertension: Silent Killer, Global Public Health Crisis. – WHO Web Portal 40p.
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