PHYSICAL QUALITY AND ANTIFUNGAL ACTIVITY OF KALANCHOE PINNATA LEAF EXTRACT OINTMENT AGAINST CANDIDA ALBICANS

Authors

  • MAKHABBAH JAMILATUN Department of Pharmaceutical and Food Analysis, Health Polytechnic of Health Ministry Surakarta, Klaten, Indonesia.
  • MEI KHOLISNA Department of Pharmaceutical and Food Analysis, Health Polytechnic of Health Ministry Surakarta, Klaten, Indonesia.
  • SUSILO YULIANTO Department of Pharmaceutical and Food Analysis, Health Polytechnic of Health Ministry Surakarta, Klaten, Indonesia.

Keywords:

antifungal, ointment, kalanchoe pinnata, candida albicans

Abstract

Candidiasis is still a problem and the increasing resistance of microbes to drugs has encouraged the search for sources of antimicrobial drugs from natural ingredients. The Kalanchoe pinnata plant contains active compounds such as flavonoids, tannins, and saponins which have the potential to act as antifungals. This research aimed to determine the physical quality and antifungal activity of Kalanchoe pinnata leaf extract ointment against Candida albicans. The method used was experimental and four formulas were made with varying concentrations of added Kalanchoe pinnata leaf extract, namely F0 (0%), F1 (5%), F2 (10%), and F3 (15%). The results of the F0 organoleptic test are yellow, semisolid, and have a characteristic ointment odor. Meanwhile, F1, F2, and F3 are brown to dark brown, semisolid, and have a distinctive smell of Kalanchoe pinnata leaf extract. The homogeneity test results show that each formula has homogeneous properties. The pH test results on F0, F1, F2, and F3 were 5.90 respectively; 5.63; 5.54; and 5.37. The spreadability test results at F0, F1, F2, and F3 were 5.77 cm, 5.61 cm, 5.39 cm, and 5.22 cm, respectively. The antifungal activity test results at F0, F1, F2, and F3 were 0 mm, 4.31 mm, 8.04 mm, and 11.50 mm, respectively. The results obtained show that Kalanchoe pinnata leaf extract can be formulated in ointment preparations and has antifungal activity, the best seen from the inhibition test is in F3 with an extract concentration of 15%.

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Published

2024-12-25

How to Cite

JAMILATUN, M., KHOLISNA, M., & YULIANTO, S. (2024). PHYSICAL QUALITY AND ANTIFUNGAL ACTIVITY OF KALANCHOE PINNATA LEAF EXTRACT OINTMENT AGAINST CANDIDA ALBICANS. Quantum Journal of Medical and Health Sciences, 3(5), 18–26. Retrieved from http://qjmhs.com/index.php/qjmhs/article/view/111

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