DEVELOPMENT OF QUICK RELIEF ACECLOFENAC DRUG FORMULATIONS BY VARIOUS SOLUBILITY ENHANCEMENT APPROACHES
Keywords:
super-disintegrants, quick relief formulations, sublimation, solid dispersion, solvent evaporationAbstract
One of the widely prescribed analgesic in INDIA & worldwide and still standing in pharma market is aceclofenac. An attempt has been done to enhance solubility of drug by formulating three different quick relief formulations as tablets, films and gels as its major limitation is its solubility. The quick relief achieved by its disintegration, with the aid of superdisintegrants in the formulation in various concentrations. Six each of three different formulations such as solvent evaporation technique for films, sublimation technique for tablets and solid dispersion incorporation technique for gels were prepared & various parameters evaluated formulation wise. The optimized formulations from overall 18 formulations were found to be as T6, QF6 and G4 with percentage drug release 96.76%, 92.43% and 90.53% respectively.
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